Open AccessCytotoxic and Antibacterial Activity of Selected Medicinal Plants used in South African Traditional Medicine
Author(s) -
Makhapa Makhafola,
Lorraine Middleton,
M. T. Olivier,
Oyinlola Oluwunmi Olaokun
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.22240
Subject(s) - antibacterial activity , lippia , traditional medicine , chemistry , cytotoxicity , aqueous extract , cytotoxic t cell , bacteria , food science , in vitro , biology , essential oil , biochemistry , medicine , genetics
Five plants were investigated for their antibacterial and cytotoxicity activities, namely: Lantana rugosa, Lippia javanica, Lippia wilmsii, Hilliardiella elaeagnoides and Withania somnifera. Four organisms and liver cells were used to evaluate the efficacy and the safety of the extracts from these plants. All the extracts showed antibacterial activity with the MIC ranging from 0.04 ± 0.04 mg/mL to 11.46 ± 9.66 mg/mL. The acetonic extract of L. javanica exhibited the highest antibacterial activity with MIC value of 0.04 ± 0.04 mg/mL against P. aeruginosa and 0.28 ± 0.35 mg/mL against S. aureus. Aqueous and acetonic extracts of L. wilmsii (LC50 > 1000 μg/mL) and the hexane extract of L. javanica (LC50 > 1000 μg/mL) were the least cytotoxic. While acetonic extract of L. javanica (0.01 ± 0.64 μg/mL) and hexane extract of L. wilmsii (0.03 ± 0.31 μg/mL) were the most cytotoxic.