Open AccessHigh Yielding, Base Catalyzed C6 Regioselective Amination and N9 Alkylation in Purine Nucleotide
Author(s) -
Gautamkumar Dhuda,
Khushal M. Kapadiya,
P. H. Ladwa,
Bhavna Godhaniya,
J. J. Modha
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.22235
Subject(s) - chemistry , morpholine , regioselectivity , amination , alkylation , purine , nucleoside , yield (engineering) , nucleotide , amine gas treating , purine metabolism , combinatorial chemistry , catalysis , organic chemistry , stereochemistry , biochemistry , enzyme , materials science , metallurgy , gene
2,6-Dichloropurine is an interesting new nucleoside which gave regioselectively various 2-derivatized or 6-derivatized purines by using a secondary amines. An efficient, simple and regioselective synthesis of C6 morpholine, N9 alkylated purine nucleoside derivatives were attained via chloro-amine coupling reaction between 2,6-dichloropurine with morpholine followed by commercial alkylation method using DMF and K2CO3. Over the traditionally used protocols and procedure, it have been exhibited advance benefits such as admirable yield, simple reaction conditions and modest influence.