Open AccessCatalyst-Free Cascade Synthesis of Densely Functionalized Chromenes in Water
Author(s) -
Subrahmanya Ishwar Bhat
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.22191
Subject(s) - chemistry , knoevenagel condensation , cascade , catalysis , yield (engineering) , aqueous solution , environmentally friendly , intramolecular force , cascade reaction , organic chemistry , michael reaction , filtration (mathematics) , combinatorial chemistry , chromatography , ecology , materials science , statistics , mathematics , metallurgy , biology
An expeditious and environmental friendly, general protocol has been developed for the synthesis of 2-amino-3-cyano-4H-chromenes via cascade Knoevenagel-Michael-intramolecular cyclization in water. Pure solid products were obtained by simple filtration technique. The aqueous catalyst-free reactions lead to high product yield at room temperature.