Open AccessA Novel Synthesis, Characterization and Biological Studies of Ferrocenyl Substituted Pyrazoles
Author(s) -
Manoj Kumar,
Shashi Sharma,
Hardeep Singh Tuli,
Rajshree Khare
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.22161
Subject(s) - chemistry , ferrocene , pyrazole , reagent , hydrazine (antidepressant) , combinatorial chemistry , natural product , iodine , proton nmr , characterization (materials science) , organic chemistry , nanotechnology , electrode , chromatography , electrochemistry , materials science
It has been discovered that ferrocenyl substituted heterocyclic compounds have wide scope of restorative methodology. The combination of ferrocenyl substituted pyrazole is the new class in these compounds with upgraded natural activity. This work center around blend of ferrocenyl substituted pyrazoles through novel course. The combination of 1-phenyl-3-ferrocenyl-pyrazole was examined including addition-cyclocondensation like response conditions. The response continued through three phases using of expansion cyclo-buildup of acetyl ferrocene with phenyl hydrazine pursued by cyclizing reagent iodine with NaHCO3. In both syntheses, each time single product isolated having good yields (87 and 79 %). Ferrocenyl substituted pyrazoles were examined by spectroscopic techniques (1H NMR, IR, MS) and their biological properties have been screened.