Open AccessSynthesis, Molecular Docking and Radical Scavenging Activity of 1,2,4,5-Tetrasubstituted Imidazole Derivatives
Author(s) -
Somashekara Bhadrachar,
Giriyapura R. Vijayakumar,
Kittappa M. Mahadevan,
Thippeswamy Basavaraja
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.22107
Subject(s) - chemistry , ceric ammonium nitrate , imidazole , dpph , antioxidant , amine gas treating , ammonium acetate , catalysis , docking (animal) , scavenging , proton nmr , organic chemistry , medicinal chemistry , combinatorial chemistry , high performance liquid chromatography , medicine , nursing , grafting , polymer
A series of 1,2,4,5-tetrasubstituted imidazoles (2a-g) were synthesized using 1,2-diketone,1-naphthaldehyde, substituted aromatic amine and ammonium acetate in the presence of ceric ammonium nitrate as a catalyst. The synthesized compounds were characterized by FT-IR, 1H NMR, Mass spectra and explored for their antioxidant activity by DPPH free radical scavenging assay method. Among the synthesized compounds 2a, 2e and 2f exhibit good antioxidant activities. Molecular docking study was also been performed to know the possible interactions between the synthesized compound and antioxidant receptor 3MNG.