Open AccessEnantio Selective Synthesis of New Phenylpropanoid: Isolated from Walsura trifoliata
Author(s) -
L.V. Ramana,
Ming Rao,
Karri Apparao,
B. Nageswara Rao
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.22064
Subject(s) - chemistry , phenylpropanoid , phloroglucinol , natural product , wittig reaction , stereochemistry , dihydroxylation , sharpless asymmetric dihydroxylation , organic chemistry , enantioselective synthesis , biosynthesis , catalysis , enzyme
A new phenylpropanoid containing flavon-3-ol has been isolated from the leaves of traditional medicinal plant, Walsura trifoliata. The structure of the compound was established on the basis of spectroscopic evidence [2D NMR, HREIMS] and by its alternative synthesis. The synthesis of this natural product was achieved from inexpensive and readily available starting materials of phloroglucinol dihydrate. Key reaction sequence includes Grubbs-II RCM reaction, Wittig reaction and sharpless dihydroxylationusing AD-mix α.