Open AccessSynthesis, Characterization and Anticonvulsant Potential of 2,5-Disubstituted 1,3,4-Oxadiazole Analogues
Author(s) -
Rajnish Kumar,
Mohd. Mustaqeem Abdullah
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.22061
Subject(s) - chemistry , anticonvulsant , oxadiazole , moiety , benzimidazole , quinoline , stereochemistry , organic chemistry , epilepsy , neuroscience , biology
A new series of compounds in which benzimidazole, oxadiazole and quinoline were incorporated, was synthesized and investigated for their anticonvulsant activity. Some of the newly synthesized compounds have shown good anticonvulsant activity. Significant anticonvulsant potency of the prepared derivatives has been evaluated by minimal electroshock and subcutaneous pentylenetetrazole animal model methods. The structure of synthesized compounds indicated that the introduction of strong electron donating groups like methoxy, amino and hydroxyl group and weak electron withdrawing halogen at phenyl ring attached to 1,3,4-oxadiazole moiety causes improvement in anticonvulsant activity. Locomotor behaviour was evaluated by actophotometer and toxicology study was also performed to evaluate their significance as required anticonvulsant compounds.