Open AccessSynthesis of New Dihydropyrazoles of Designed Curcumin Analogues
Author(s) -
Vishwa Deepak Tripathi
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.22023
Subject(s) - chemistry , chalcone , substituent , phenylhydrazine , ring (chemistry) , curcumin , carbon 13 nmr , reactivity (psychology) , proton nmr , pyrazole , electronic effect , stereochemistry , computational chemistry , medicinal chemistry , organic chemistry , steric effects , medicine , biochemistry , alternative medicine , pathology
Present work demonstrates a facile synthesis of a series of 20 dihydropyrazole derivatives from well designed curcumin analogues by reaction of chalcone derivatives with phenylhydrazine. All the synthesized compounds were characterized by spectroscopic (1H and 13C NMR, IR spectra), spectrometric (Mass spectra) data and elemental analysis. Synthesized dihydropyrazoles have diversity points on attached phenyl ring. Effect of substituent on reactivity was explained on the basis of electronic effect generated due to groups on phenyl ring. Presence of dd (double doublet) in 1H NMR spectrum of dihydropyrazoles was also explained due to presence of optically active carbon of pyrazole ring.