Open AccessStructure Activity Relationship, Drug Likeness and Evaluation of Antioxidant Activity of Some Mannich Bases of Dihydropyrimidinones
Author(s) -
Ravinder Mamidala,
Solomon Raj S. Bhimathati,
Aparna Vema
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.22008
Subject(s) - chemistry , ascorbic acid , antioxidant , mannich base , mannich reaction , radical , scavenging , drug , microwave irradiation , organic chemistry , pharmacology , food science , catalysis , medicine
A series of 21 O- and N-Mannich bases of 3,4-dihydropyrimidinones (2a-j and 3a-k) were synthesized by using microwave irradiation technique by multi-component reaction in two steps. All the compounds were evaluated for their free radical scavenging activity by four methods. Structure activity relationship studies revealed that the compounds 2h, 2g, 3h and 3g exhibited profound antioxidant properties compared to standard ascorbic acid. Among O- and N-Mannich bases, N-Mannich bases were found to be more potent in scavenging free radicals. The correlation between structure and activities of these compounds with concern to drug likeliness profile and other physico-chemical parameters are portrayed and verified experimentally.