Open AccessWater-Mediated Ceric Ammonium Nitrate Catalyzed C-C/C-N Bond Formation: Convenient Access to Polyfunctionalized Pyrazoles via Multicomponent Reaction
Author(s) -
Vikas D. Kadu,
Mahesh G. Hublikar,
Dattatraya G. Raut,
Raghunath B. Bhosale
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.21947
Subject(s) - ceric ammonium nitrate , chemistry , malononitrile , catalysis , aqueous solution , organic chemistry , yield (engineering) , ammonium nitrate , green chemistry , polyethylene glycol , solvent , nitrate , combinatorial chemistry , reaction mechanism , polymer , grafting , materials science , metallurgy
An efficient multicomponent approach has been developed in the environmentally green aqueous medium for synthesis of substituted polyfunctionalized pyrazoles. The simple and readily available aldehydes, malononitrile and phenylhydrazines substrates afforded polysubstituted imidazoles (15 examples) up to 96 % yield. The polyethylene glycol is playing the dual role of solvent and promoter with water in this reaction catalyzed by ceric ammonium nitrate.