Open AccessPreparation and Characterization of Polyethylene Glycol Coating Iron Oxide Nanoparticles for Curcumin Delivery
Author(s) -
Nguyễn Thị Thanh Thủy,
Lê Đức Anh,
Nguyen Huu Tri,
Cù Văn Hoàng,
Nguyen Anh Nhut
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.21941
Subject(s) - curcumin , sonication , polyethylene glycol , coprecipitation , chemistry , nanoparticle , nuclear chemistry , peg ratio , iron oxide nanoparticles , fourier transform infrared spectroscopy , iron oxide , chemical engineering , nanotechnology , chromatography , inorganic chemistry , materials science , organic chemistry , biochemistry , engineering , finance , economics
The PEG-coated iron oxide nanoparticles (Fe3O4 NPs-PEG) was synthesized by coprecipitation and ultrasonication method. X-ray diffraction results exhibited that the average size of Fe3O4 NPs-PEG was 19.10 nm, which was further confirmed in TEM imaging. In addition, sonication time and curcumin concentration were studied to evaluate the efficiency of loading curcumin onto Fe3O4 NPs-PEG. Further, statistical optimization using response surface methodology (RSM) has shown curcumin concentration (0,01% w/v) and sonication time (21 min) for maximal curcumin loading (0.37 mg/g). Along with the magnetization studies, the immobilization of curcumin onto the Fe3O4 NPs-PEG was characterized by UV, FTIR and SEM. The results showed that the curcumin loaded PEG coated iron oxide nanoparticles could potentially be used for magnetically target drug delivery.