Open AccessSynthesis and Antimicrobial Activity of Piperine Analogues Containing 1,2,4-Triazole Ring
Author(s) -
Kottakki Naveen Kumar,
Karteek Rao Amperayani,
V. Ravi Sankar Ummdi,
Umadevi Parimi
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.21876
Subject(s) - chemistry , piperine , bacillus cereus , antimicrobial , staphylococcus aureus , gram , antibacterial activity , pseudomonas aeruginosa , cereus , 1,2,4 triazole , proton nmr , triazole , stereochemistry , carbon 13 nmr , bacteria , organic chemistry , genetics , biology
A series 1,2,4-triazole piperine analogues (TP1-TP6) were designed and synthesized. The structures were confirmed using 1H NMR and 13C NMR. Antibacterial study was done using Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative micro-organisms (E. coli and Pseudomonas aeruginosa) by disc diffusion method. Compound containing chloro substitution (TP6) showed the highest effect, while compound TP1, TP3, TP4, TP5 showed the moderate activity.