Open AccessAntifungal Activity of Synthesized Benzothiazole Derivatives using Structure Activity Relationship
Author(s) -
Madhu Toshniwal,
Mahendra Bundel,
RAVIKANT RAVIKANT,
Arvind Pareek
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.21858
Subject(s) - benzothiazole , chemistry , antifungal , ketone , antifungal drug , drug , proton nmr , combinatorial chemistry , elemental analysis , carbon 13 nmr , stereochemistry , organic chemistry , pharmacology , medicine , dermatology
In the field of drug discovery the benzothiazole is found to be a magical compound. Computational tools were used to predict their molecular property, drug likeness, overall drug score and toxicity risks which are essential parameter for a chemical to be qualified as a drug. As good results were observed by computational tools then novel series of 2-amino-6-substituted benzothiazoles with halo ketone have been synthesized by conventional method. All the synthesized compounds have been characterized by elemental analysis and IR, 1H NMR data in full accordance with their expected (depicted) structures. The synthesized compounds were screened for their antifungal activity using standard drug ampicillin.