Open AccessNovel and Environmentally Friendly Synthesis of Pimavanserin (5-HT2A Receptor)
Author(s) -
Rajesh Kumar Rapolu,
V. V. Raju,
Murthy Chavali,
Naveen Mulakayala
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.21808
Subject(s) - environmentally friendly , chemistry , benzylamine , solvent , biochemical engineering , combinatorial chemistry , organic chemistry , ecology , engineering , biology
Eco-friendly synthesis of pimavanserin was developed from the key starting material 4-isobutoxy benzylamine in three different routes using water as solvent. These reactions provide an advantage of easy workup, good yields of products and uses water as the solvent. No column purification was required for the isolation of the product.