Open AccessSynthesis, Characterization and Biological Studies of Novel Schiff Base viz. Bis-1,1'-(pyridine-2,6-diyldieth-1-yl-1-ylidene) biguanidine and Their Transition Metal Complexes
Author(s) -
Manoj Kumar,
Pallvi,
Hardeep Singh Tuli,
Rajshree Khare
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.21732
Subject(s) - chemistry , schiff base , cobalt , transition metal , nickel , pyridine , metal , trichophyton rubrum , condensation reaction , ligand (biochemistry) , antimicrobial , cleavage (geology) , stereochemistry , nuclear chemistry , polymer chemistry , medicinal chemistry , organic chemistry , antifungal , catalysis , biochemistry , microbiology and biotechnology , receptor , geotechnical engineering , fracture (geology) , biology , engineering
Novel Schiff base and its two transition metal complexes derived from the condensation reaction of 2,6-diacetylpyridine with biguanide, characterized by 1H NMR, IR and elemental analysis. The ligand and its cobalt(II) and nickel(II) complexes showed potent DNA photo-cleavage activity. Antimicrobial activity of this Schiff base and its cobalt(II) and nickel(II) complexes against bacteria and fungi viz. S. aureus, K. pneumoniaae and A. niger, Trichophyton rubrum, respectively was evaluated in terms of zone of inhibition.