Open AccessSchiff Base Metal Complexes as Anticancer Agents
Author(s) -
G. Sridevi,
S. Arul Antony,
R. Angayarkani
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.21697
Subject(s) - chemistry , metal , combinatorial chemistry , ligand (biochemistry) , metal ions in aqueous solution , bioinorganic chemistry , in vivo , stereochemistry , nanotechnology , biophysics , biochemistry , organic chemistry , microbiology and biotechnology , receptor , materials science , biology
Cutting-edge practices in bioinorganic chemistry are pivotal for enhancing the layout of compounds to lessen poisonous facet effect and recognize their mechanism of action. A powerful anticancer agent should own inherent, inhibitory property and also delivery, dosage and residence time in vivo. Organic function and conformation of mutated gene may be altered by way of binding of metal ions. Upswing of activities counting on the structural data, intending in enhancing and growing different forms of metal based compounds, continuous seek of extra metal based compounds have been synthesized via revamping the prevailing chemical shape via ligand substitution. The prevailing paper addresses the trendy development in the design of novel antitumor agents primarily based on transition metal complex via highlighting the near dating among their structural alternatives and cytotoxic ability.