Open AccessModified Biginelli Reaction: Synthesis of Pyrimidoquinoline Derivatives
Author(s) -
V. Nadaraj,
S. Thamarai Selvi,
M. Abirami
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.21600
Subject(s) - chemistry , biginelli reaction , pyrimidine , urea , quinolone , elemental analysis , organic chemistry , combinatorial chemistry , microwave irradiation , stereochemistry , catalysis , antibiotics , biochemistry
Compounds having quinolone and pyrimidine skeleton plays an important role in the medicinal chemistry. The objective of the present work was to modify the Biginelli reaction by using heterocylic ketones under microwave condition. We have demonstrated new synthetic route of quinolone fused 1,4-dipyrimidines by the reaction of 6-methyl-4-hyrdoxyquinolin-2(1H)-one (1), substituted aromatic aldehydes (2a-g) with phenyl urea (3). The structure of these newly synthesized compounds was characterized IR, NMR, Mass spectral and elemental analysis.