Open AccessSynthesis, Characterization and Biological Evaluation of Isoxazoles Derived from 3-Aminoacetophenone
Author(s) -
Tarun Kumar,
Shreemoyee Kumar,
Narayanaswamy Srinivasan
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.21165
Subject(s) - antimycobacterial , chemistry , in vivo , in vitro , proton nmr , biological activity , stereochemistry , combinatorial chemistry , nuclear chemistry , mycobacterium tuberculosis , biochemistry , tuberculosis , medicine , microbiology and biotechnology , pathology , biology
Isoxazoles were synthesized by condensing different aldehydes with 3-aminoacetophenone coupled to N-methyl piperazines. All the compounds were screened for anticancer activity against human breast cancer cell lines- MCF-7 and MDA-MB-468. The antimycobacterial activity of compounds were assessed against M. tuberculosis using microplate alamar blue assay (MABA). The structures of newly synthesized compounds established on the basis of their m.p., TLC, FTIR, mass and 1H NMR data. The results of antimycobacterial and anticancer studies shows that some of it posses mild to moderate activity against standard. These new synthesized compounds were identified and characterized, demonstrated antitubercular, in vivo efficacy in tumor models like MCF-7 and MDA-MB-468.