Open AccessLoss of ARID1A Promotes Hepatocellular Carcinoma Progression via Up-regulation of MYC Transcription
Author(s) -
Yao Xiao,
Guodong Liu,
Xiwu Ouyang,
Denggao Zai,
Jixiang Zhou,
Xiaoli Li,
Qi Zhang,
Jie Zhao
Publication year - 2021
Publication title -
journal of clinical and translational hepatology
Language(s) - English
Resource type - Journals
eISSN - 2310-8819
pISSN - 2225-0719
DOI - 10.14218/jcth.2021.00111
Subject(s) - arid1a , hepatocellular carcinoma , medicine , cancer research , transcription factor , oncology , gene , biology , genetics , mutation
AT-rich interactive domain-containing protein 1A (ARID1A) is frequently mutated or deficient in hepatocellular carcinoma (HCC). However, the role of ARID1A in HCC remains unclear. Therefore, the biological role of ARID1A in HCC was evaluated and a potential mechanism was investigated.