Reciprocal interactions between mesenchymal stem cells and macrophages | Zendy

M. Kloc | Zendy; Ahmed Uosef | Zendy; Monika Leśniak | Zendy; Jacek Z. Kubiak | Zendy; R. Mark Ghobrial | Zendy

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Reciprocal interactions between mesenchymal stem cells and macrophages

Author(s) -

M. Kloc,

Ahmed Uosef,

Monika Leśniak,

Jacek Z. Kubiak,

R. Mark Ghobrial

Publication year - 2020

Publication title -

the international journal of developmental biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.837

H-Index - 103

eISSN - 1696-3547

pISSN - 0214-6282

DOI - 10.1387/ijdb.200242jc

Subject(s) - mesenchymal stem cell , biology , phenotype , microbiology and biotechnology , macrophage , immune system , regeneration (biology) , immunology , stem cell , cancer research , in vitro , genetics , gene

Mesenchymal stem cells (MSCs) are used as therapeutic agents for the treatment of a wide spectrum of diseases, as well as for the regeneration and healing of burns and wounds. MSCs have an immunomodulatory effect and influence the phenotype and functions of immune cells, including macrophages, which in turn prime and license the MSCs. We discuss the new findings on the feedback loop between MSCs and macrophages and its consequences on the outcome of MSC therapies.

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