Open AccessReciprocal interactions between mesenchymal stem cells and macrophages
Author(s) -
Małgorzata Kloc,
Ahmed Uosef,
Monika Leśniak,
Jacek Z. Kubiak,
Rafik M. Ghobrial
Publication year - 2020
Publication title -
the international journal of developmental biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.837
H-Index - 103
eISSN - 1696-3547
pISSN - 0214-6282
DOI - 10.1387/ijdb.200242jc
Subject(s) - mesenchymal stem cell , biology , phenotype , immunology , immune system , microbiology and biotechnology , macrophage , regeneration (biology) , stem cell , clinical uses of mesenchymal stem cells , cancer research , in vitro , adult stem cell , genetics , endothelial stem cell , gene
Mesenchymal stem cells (MSCs) are used as therapeutic agents for the treatment of a wide spectrum of diseases, as well as for the regeneration and healing of burns and wounds. MSCs have an immunomodulatory effect and influence the phenotype and functions of immune cells, including macrophages, which in turn prime and license the MSCs. We discuss the new findings on the feedback loop between MSCs and macrophages and its consequences on the outcome of MSC therapies.