Open AccessPrimordial germ cell migration
Author(s) -
Kathleen Molyneaux,
Christopher Wylie
Publication year - 2004
Publication title -
the international journal of developmental biology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.837
H-Index - 103
eISSN - 1696-3547
pISSN - 0214-6282
DOI - 10.1387/ijdb.041833km
Subject(s) - biology , microbiology and biotechnology , cell migration , cell adhesion , chemotaxis , zebrafish , motility , receptor , receptor tyrosine kinase , cell , cell growth , signal transduction , genetics , gene
Mutational and antisense screens in Drosophila and zebrafish, and transcriptional profiling and time-lapse analysis in the mouse, have contributed greatly to our understanding of PGC development. In all three systems, the behavior of PGCs is controlled by growth factors which signal through G-protein coupled receptors and/or tyrosine kinase receptors. Additionally, regulated cell-cell and cell-substrate adhesion is important for PGC motility. Finally, localized growth factors may control PGC survival and consequently PGC position. Chemotaxis, regulated adhesion and cell survival are important for multiple migration processes which occur during development and disease. PGC migration shares these features.