Open AccessClofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice
Author(s) -
Sandrine Belouzard,
Arnaud Machelart,
Valentin Sencio,
Thibaut Vausselin,
Eik Hoffmann,
Nathalie Deboosère,
Yves Rouillé,
Lowiese Desmarets,
Karin Séron,
Adeline Danneels,
Cyril Robil,
Loïc Belloy,
Camille Moreau,
Catherine Piveteau,
Alexandre Biela,
Alexandre Vandeputte,
Séverine Heumel,
Lucie Deruyter,
Julie Dumont,
Florence Leroux,
Ilka Engelmann,
Enag Kazali Alidjinou,
Didier Hober,
Priscille Brodin,
Terence Beghyn,
François Trottein,
Benoît Déprez,
Jean Dubuisson
Publication year - 2022
Publication title -
plos pathogens
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.719
H-Index - 206
eISSN - 1553-7374
pISSN - 1553-7366
DOI - 10.1371/journal.ppat.1010498
Subject(s) - vero cell , drug repositioning , potency , pharmacology , drug , lung , drug discovery , viral replication , drug development , covid-19 , virology , antiviral drug , genetically modified mouse , biology , respiratory tract , pharmacokinetics , viral load , respiratory system , medicine , virus , transgene , gene , in vitro , pathology , bioinformatics , infectious disease (medical specialty) , disease , biochemistry