Advances and gaps in SARS-CoV-2 infection models | Zendy

César MuñozFontela | Zendy; Lina Widerspick | Zendy; Randy A. Albrecht | Zendy; Martin Beer | Zendy; Miles W. Carroll | Zendy; Emmie de Wit | Zendy; Michael Diamond | Zendy; William E. Dowling | Zendy; Simon G. P. Funnell | Zendy; Adolfo Garcı́a-Sastre | Zendy; Nora M. Gerhards | Zendy; Rineke de Jong | Zendy; Vincent J. Munster | Zendy; Johan Neyts | Zendy; Stanley Perlman | Zendy; Douglas S. Reed | Zendy; Jüergen A. Richt | Zendy; Ximena Riveros-Balta | Zendy; Chad J. Roy | Zendy; Francisco J. Salguero | Zendy; Michael Schotsaert | Zendy; Lauren M. Schwartz | Zendy; Robert A. Seder | Zendy; Joaquím Segalés | Zendy; Seshadri S. Vasan | Zendy; Ana María Henao-Restrepo | Zendy; Dan H. Barouch | Zendy

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Advances and gaps in SARS-CoV-2 infection models

Author(s) -

César MuñozFontela,

Lina Widerspick,

Randy A. Albrecht,

Martin Beer,

Miles W. Carroll,

Emmie de Wit,

Michael Diamond,

William E. Dowling,

Simon G. P. Funnell,

Adolfo Garcı́a-Sastre,

Nora M. Gerhards,

Rineke de Jong,

Vincent J. Munster,

Johan Neyts,

Stanley Perlman,

Douglas S. Reed,

Jüergen A. Richt,

Ximena Riveros-Balta,

Chad J. Roy,

Francisco J. Salguero,

Michael Schotsaert,

Lauren M. Schwartz,

Robert A. Seder,

Joaquím Segalés,

Seshadri S. Vasan,

Ana María Henao-Restrepo,

Dan H. Barouch

Publication year - 2022

Publication title -

plos pathogens

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.719

H-Index - 206

eISSN - 1553-7374

pISSN - 1553-7366

DOI - 10.1371/journal.ppat.1010161

Subject(s) - covid-19 , disease , animal model , coronavirus , transmission (telecommunications) , pandemic , infectious disease (medical specialty) , virology , medicine , biology , immunology , computer science , outbreak , telecommunications , pathology , endocrinology

The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.

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