Open AccessImmunological exhaustion: How to make a disparate concept operational?
Author(s) -
Hannah Kaminski,
Maël Lemoine,
Thomas Pradeu
Publication year - 2021
Publication title -
plos pathogens
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.719
H-Index - 206
eISSN - 1553-7374
pISSN - 1553-7366
DOI - 10.1371/journal.ppat.1009892
Subject(s) - computer science , computational biology , epistemology , intensive care medicine , immunology , medicine , biology , philosophy
In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational.