Binding and entering: COVID finds a new home | Zendy

Michelle N. Vu | Zendy; Vineet D. Menachery | Zendy

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Binding and entering: COVID finds a new home

Author(s) -

Michelle N. Vu,

Vineet D. Menachery

Publication year - 2021

Publication title -

plos pathogens

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.719

H-Index - 206

eISSN - 1553-7374

pISSN - 1553-7366

DOI - 10.1371/journal.ppat.1009857

Subject(s) - coronavirus , virology , middle east respiratory syndrome coronavirus , transmissibility (structural dynamics) , covid-19 , pandemic , virus , severe acute respiratory syndrome coronavirus , biology , protease , middle east respiratory syndrome , betacoronavirus , medicine , outbreak , infectious disease (medical specialty) , enzyme , pathology , vibration , biochemistry , physics , disease , vibration isolation , quantum mechanics

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged as a virus with a pathogenicity closer to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and a transmissibility similar to common cold coronaviruses (CoVs). In this review, we briefly discuss the features of the receptor-binding domain (RBD) and protease cleavage of the SARS-CoV-2 spike protein that enable SARS-CoV-2 to be a pandemic virus.

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