Open AccessThree-dimensional chromatin in infectious disease—A role for gene regulation and pathogenicity?
Author(s) -
Sage Z. Davis,
Thomas Hollin,
Todd Lenz,
Karine G. Le Roch
Publication year - 2021
Publication title -
plos pathogens
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.719
H-Index - 206
eISSN - 1553-7374
pISSN - 1553-7366
DOI - 10.1371/journal.ppat.1009207
Subject(s) - biology , infectious disease (medical specialty) , chromatin , genome , disease , pathogenicity , chromosome conformation capture , genetics , gene , pandemic , computational biology , virology , covid-19 , gene expression , medicine , enhancer , pathology , microbiology and biotechnology
The recent Coronavirus Disease 2019 pandemic has once again reminded us the importance of understanding infectious diseases. One important but understudied area in infectious disease research is the role of nuclear architecture or the physical arrangement of the genome in the nucleus in controlling gene regulation and pathogenicity. Recent advances in research methods, such as Genome-wide chromosome conformation capture using high-throughput sequencing (Hi-C), have allowed for easier analysis of nuclear architecture and chromosomal reorganization in both the infectious disease agents themselves as well as in their host cells. This review will discuss broadly on what is known about nuclear architecture in infectious disease, with an emphasis on chromosomal reorganization, and briefly discuss what steps are required next in the field.