Open AccessIL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection
Author(s) -
Ara Lee,
Seung Pyo Park,
Chan Hee Park,
Byung Hyun Kang,
Seong Hoe Park,
Sang Jun Ha,
Kyeong Cheon Jung
Publication year - 2015
Publication title -
plos pathogens
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.719
H-Index - 206
eISSN - 1553-7374
pISSN - 1553-7366
DOI - 10.1371/journal.ppat.1005193
Subject(s) - innate immune system , biology , immunology , cytotoxic t cell , population , cd8 , lymphocytic choriomeningitis , virology , immune system , medicine , genetics , in vitro , environmental health
Memory-like CD8 + T cells expressing eomesodermin are a subset of innate T cells initially identified in a number of genetically modified mice, and also exist in wild mice and human. The acquisition of memory phenotype and function by these T cells is dependent on IL–4 produced by PLZF + innate T cells; however, their physiologic function is still not known. Here we found that these IL-4-induced innate CD8 + T cells are critical for accelerating the control of chronic virus infection. In CIITA-transgenic mice, which have a substantial population of IL-4-induced innate CD8 + T cells, this population facilitated rapid control of viremia and induction of functional anti-viral T-cell responses during infection with chronic form of lymphocytic choriomeningitis virus. Characteristically, anti-viral innate CD8 + T cells accumulated sufficiently during early phase of infection. They produced a robust amount of IFN-γ and TNF-α with enhanced expression of a degranulation marker. Furthermore, this finding was confirmed in wild-type mice. Taken together, the results from our study show that innate CD8 + T cells works as an early defense mechanism against chronic viral infection.