Open AccessInhibiting glutamine utilization creates a synthetic lethality for suppression of ATP citrate lyase in KRas-driven cancer cells
Author(s) -
Ahmet Hatipoğlu,
Deepak Me,
Talia Levy,
María A. Frías,
David A. Foster
Publication year - 2022
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0276579
Subject(s) - atp citrate lyase , synthetic lethality , glutamine , cancer cell , chemistry , biochemistry , adenosine triphosphate , cancer , microbiology and biotechnology , biology , enzyme , citrate synthase , genetics , dna repair , amino acid , gene