Open Access13-amino derivatives of dehydrocostus lactone display greatly enhanced selective toxicity against breast cancer cells and improved binding energies to protein kinases in silico
Author(s) -
Douglas Kemboi,
Moses K. Langat,
Xavier SiweNoundou,
Tendamudzimu Tshiwawa,
Rui W. M. Krause,
Candace Davison,
Christie Jane Smit,
JoAnne de la Mare,
Vuyelwa J. Tembu
Publication year - 2022
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0271389
Subject(s) - lactone , chemistry , mcf 7 , docking (animal) , selectivity , cancer cell , cytotoxicity , stereochemistry , amino acid , breast cancer , biochemistry , cancer , in vitro , human breast , medicine , nursing , catalysis
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