Open AccessThe hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation
Author(s) -
Tania Rahim,
Madison Levinson,
Kelly E. W. Carufe,
M.J. Burak,
Rithy Meas,
Stephen E. Maher,
Alfred L.M. Bothwell,
Naomi M. Gades,
Joann B. Sweasy
Publication year - 2022
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0267913
Subject(s) - systemic lupus erythematosus , immunology , anti nuclear antibody , haematopoiesis , bone marrow , immune system , autoimmune disease , biology , disease , autoantibody , mutation , medicine , antibody , stem cell , pathology , genetics , gene
Systemic lupus erythematosus is a chronic disease characterized by autoantibodies, renal and cutaneous disease, and immune complex formation. Emerging evidence suggests that aberrant DNA repair is an underlying mechanism of lupus development. We previously showed that the POLB Y265C/C mutation, which results in development of an aberrant immune repertoire, leads to lupus-like disease in mice. To address whether the hematopoietic compartment is sufficient for lupus development, we transplanted bone marrow cells from POLB Y265C/C and POLB +/+ into wild-type congenic mice. Only mice transplanted with the POLB Y265C/C bone marrow develop high levels of antinuclear antibodies and renal disease. In conclusion, we show that the hematopoietic compartment harvested from the POLB Y265C/C mice is sufficient for development of autoimmune disease.