Open AccessAcquired chemoresistance drives spatial heterogeneity, chemoprotection and collective migration in pancreatic tumor spheroids
Author(s) -
Fredrik I. Thege,
Ian I. Cardle,
Conor Gruber,
Megan J. Siemann,
Sophie H. Cong,
Katharina Wittmann,
Justin Love,
Brian J. Kirby
Publication year - 2022
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0267882
Subject(s) - biology , cancer research , pancreatic cancer , cancer cell , ribonucleotide reductase , population , cell migration , cell sorting , phenotype , cell culture , cancer , cancer stem cell , tumor microenvironment , somatic evolution in cancer , gemcitabine , cell , microbiology and biotechnology , genetics , protein subunit , gene , medicine , environmental health