Open AccessBOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved anti-cell line derived tumor xenograft activity
Author(s) -
Taylor Hickman,
Eugene Choi,
Kathleen R. Whiteman,
Sujatha Muralidharan,
Tapasya Pai,
Tyler Johnson,
Avani Parikh,
Taylor Friedman,
Madaline Gilbert,
Binzhang Shen,
Luke Barron,
Kathleen E. McGinness,
Seth A. Ettenberg,
Greg Motz,
Glen J. Weiss,
Amy Jensen-Smith
Publication year - 2022
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0266980
Subject(s) - chimeric antigen receptor , cancer research , tumor microenvironment , in vivo , t cell , cell culture , cell , immunotherapy , cancer , biology , medicine , immunology , immune system , genetics , microbiology and biotechnology , tumor cells