Open AccessUse of CRISPR/Cas9 with homology-directed repair to silence the human topoisomerase IIα intron-19 5’ splice site: Generation of etoposide resistance in human leukemia K562 cells
Author(s) -
Víctor Agmo Hernández,
Jessika CarvajalMoreno,
Xinyi Wang,
Maciej Pietrzak,
Jack C. Yalowich,
Terry S. Elton
Publication year - 2022
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0265794
Subject(s) - biology , microbiology and biotechnology , intron , exon , etoposide , gene , genetics , chemotherapy