Open AccessHigh mortality among hospitalized adult patients with COVID-19 pneumonia in Peru: A single centre retrospective cohort study
Author(s) -
Guiliana Mas-Ubillús,
Pedro Ortiz-Saavedra,
Jorge Huaringa-Marcelo,
Paola Sarzo-Miranda,
Patricia Muñoz-Aguirre,
Alejandra Díaz-Ramos,
Kattia Arribasplata-Purizaca,
Doris Mendoza,
Juan Rojas-Poma,
Cristian Marcelo-Ruiz,
Pedro Ayala-Diaz,
Edwin Hidalgo-Arroyo,
Lourdes Tupia-Cespedes
Publication year - 2022
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0265089
Subject(s) - medicine , retrospective cohort study , pneumonia , mortality rate , diabetes mellitus , cohort , cohort study , pediatrics , endocrinology
Background Peru is the country with the world’s highest COVID-19 death rate per capita. Characteristics associated with increased mortality among adult patients with COVID-19 pneumonia in this setting are not well described. Methods Retrospective, single-center cohort study including 1537 adult patients hospitalized with a diagnosis of SARS-CoV-2 pneumonia between May 2020 and August 2020 at a national hospital in Lima, Peru. The primary outcome measure was in-hospital mortality. Results In-hospital mortality was 49.71%. The mean age was 60 ± 14.25 years, and 68.38% were males. We found an association between mortality and inflammatory markers, mainly leukocytes, D-dimer, lactate dehydrogenase, C-reactive protein and ferritin. A multivariate model adjusted for age, hypertension, diabetes mellitus, and corticosteroid use demonstrated that in-hospital mortality was associated with greater age (RR: 2.01, 95%CI: 1.59–2.52) and a higher level of oxygen requirement (RR: 2.77, 95%CI: 2.13–3.62). Conclusions: In-hospital mortality among COVID-19 patients in Peru is high and is associated with greater age and higher oxygen requirements.