Open AccessDeep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson’s Disease
Author(s) -
Kati Valkonen,
Jyrki P. Mäkelä,
Katja Airaksinen,
Jussi Nurminen,
Riku Kivisaari,
Hanna Renvall,
Eero Pekkonen
Publication year - 2022
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0264333
Subject(s) - deep brain stimulation , magnetoencephalography , subthalamic nucleus , neuroscience , neurostimulation , parkinson's disease , auditory cortex , motor cortex , stimulus (psychology) , neuroplasticity , medicine , transcranial magnetic stimulation , psychology , stimulation , disease , electroencephalography , pathology , psychotherapist
Deep brain stimulation (DBS) has proven its clinical efficacy in Parkinson’s disease (PD), but its exact mechanisms and cortical effects continue to be unclear. Subthalamic (STN) DBS acutely modifies auditory evoked responses, but its long-term effect on auditory cortical processing remains ambiguous. We studied with magnetoencephalography the effect of long-term STN DBS on auditory processing in patients with advanced PD. DBS resulted in significantly increased contra-ipsilateral auditory response latency difference at ~100 ms after stimulus onset compared with preoperative state. The effect is likely due to normalization of neuronal asynchrony in the auditory pathways. The present results indicate that STN DBS in advanced PD patients has long-lasting effects on cortical areas outside those confined to motor processing. Whole-head magnetoencephalography provides a feasible tool to study motor and non-motor neural networks in PD, and to track possible changes related to cortical reorganization or plasticity induced by DBS.