Open AccessNovel prognostic determinants of COVID-19-related mortality: A pilot study on severely-ill patients in Russia
Author(s) -
К. А. Рубина,
Anna Shmakova,
А. К. Шабанов,
Yulii V. Andreev,
Н. В. Боровкова,
В. В. Кулабухов,
Anatoliy K. Evseev,
К. А. Попугаев,
С. С. Петриков,
Е. В. Семина
Publication year - 2022
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0264072
Subject(s) - covid-19 , medicine , pandemic , severity of illness , intensive care medicine , immunology , disease , infectious disease (medical specialty)
COVID-19 pandemic has posed a severe healthcare challenge calling for an integrated approach in determining the clues for early non-invasive diagnostics of the potentially severe cases and efficient patient stratification. Here we analyze the clinical, laboratory and CT scan characteristics associated with high risk of COVID-19-related death outcome in the cohort of severely-ill patients in Russia. The data obtained reveal that elevated dead lymphocyte counts, decreased early apoptotic lymphocytes, decreased CD14+/HLA-Dr+ monocytes, increased expression of JNK in PBMCs, elevated IL-17 and decreased PAI-1 serum levels are associated with a high risk of COVID-19-related mortality thus suggesting them to be new prognostic factors. This set of determinants could be used as early predictors of potentially severe course of COVID-19 for trials of prevention or timely treatment.