Open AccessEfficacy of a dietary supplement in dogs with osteoarthritis: A randomized placebo-controlled, double-blind clinical trial
Author(s) -
Elisa Martello,
Mauro Bigliati,
Raffaella Adami,
Elena Biasibetti,
Donal Bisanzio,
Giorgia Meineri,
Natascia Bruni
Publication year - 2022
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0263971
Subject(s) - medicine , placebo , osteoarthritis , dietary supplement , boswellia serrata , randomized controlled trial , clinical trial , double blind , glucosamine , chondroitin sulfate , physical therapy , food science , alternative medicine , chemistry , organic chemistry , pathology , anatomy , glycosaminoglycan
This study is a randomized, placebo-controlled, double-blinded trial performed to investigate the effects of a dietary supplement containing a mixture of Boswellia serrata Roxb., chlorophyll, green tea extract, glucosamine, chondroitin sulfate, hyaluronic acid, and further in the manuscript: non-hydrolised type II collagen in dogs with osteoarthritis (OA). A total of 40 dogs were enrolled in the study, they were randomly divided in control (CTR) and treatment (TRT) groups. The TRT group received the dietary supplement for 60 days. The CTR group received a placebo for the same number of days. All the subjects had veterinary evaluations during the trial and owners were requested to fill in questionnaires on chronic pain using the Helsinki Chronic Pain Index. The product was easy to administer and no side effects were reported. Combining results from veterinarian and owner evaluations, the tested product proved to be significantly beneficial in alleviating pain and in reducing the clinical signs in dogs with OA.