Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant | Zendy

Miao Tian | Zendy; Kazufumi Mochizuki | Zendy; Josef Loidl | Zendy

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Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant

Author(s) -

Miao Tian,

Kazufumi Mochizuki,

Josef Loidl

Publication year - 2022

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0263691

Subject(s) - meiosis , chiasma , tetrahymena , homologous chromosome , anaphase , biology , homologous recombination , mutant , prophase , microbiology and biotechnology , genetics , bivalent (engine) , chromosomal crossover , dna , gene , chromosome , chemistry , organic chemistry , metal

Meiotic DNA double-strand breaks produce reciprocally exchanged DNA strands, which mature into chiasmata that hold homologous chromosomes together as bivalents. These bivalents are subsequently separated in the first meiotic division. In a mutant lacking the newly identified Tetrahymena gene APRO1 (Anaphase promoting 1), meiosis is arrested by the end of prophase. Mature chiasmata are not formed but bivalents are connected via a molecular precursor structure. In-depth analysis of this arrested intermediate structure may help to elucidate the noncanonical molecular recombination pathway in Tetrahymena .

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