Open Accessd-allulose protects against diabetic nephropathy progression in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes
Author(s) -
Misato Niibo,
Akane Kanasaki,
Takuya Iida,
Keisuke Ohnishi,
Taro Ozaki,
Kazuya Akimitsu,
Tohru Minamino
Publication year - 2022
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0263300
Subject(s) - diabetic nephropathy , medicine , endocrinology , proinflammatory cytokine , diabetes mellitus , inflammation
d -allulose is a rare sugar that has been reported to possess anti-hyperglycemic effects. In the present study, we hypothesized that d -allulose is effective in attenuating the progression of diabetic nephropathy in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat model of type 2 diabetes mellitus. Drinking water with or without 3% d -allulose was administered to OLETF rats for 13 weeks. Long-Evans Tokushima Otsuka rats that received drinking water without d -allulose were used as non-diabetic control rats. d -allulose significantly attenuated the increase in blood glucose levels and progressive mesangial expansion in the glomerulus, which is regarded as a characteristic of diabetic nephropathy, in OLETF rats. d -allulose also attenuated the significant increases in renal IL-6 and tumor necrosis factor-α mRNA levels in OLETF rats, which is a proinflammatory parameter. Additionally, we showed that d -allulose suppresses mesangial matrix expansion, but its correlation with suppressing renal inflammation in OLETF rats should be investigated further. Collectively, our results support the hypothesis that d -allulose can prevent diabetic nephropathy in rats.