Open AccessBifidobacterium lactis BL-99 modulates intestinal inflammation and functions in zebrafish models
Author(s) -
Meng Chen,
Chinfeng Liu,
Mingzhu Dai,
Qinwen Wang,
Chunqi Li,
WeiLian Hung
Publication year - 2022
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0262942
Subject(s) - zebrafish , biology , inflammation , gastrointestinal tract , goblet cell , microbiology and biotechnology , immunology , epithelium , biochemistry , gene , genetics
This study was designed to explore the therapeutics and the mechanisms of a patented and marked gastric acid and intestine juice-resistant probiotics Bifidobacterium lactis BL-99 ( B . lactis BL-99) on the intestinal inflammation and functions in the zebrafish models. After feeding for 6 hours, B . lactis BL-99 was fully retained in the larval zebrafish intestinal tract and stayed for over 24 hours. B . lactis BL-99 promoted the intestinal motility and effectively alleviated aluminum sulfate-induced larval zebrafish constipation ( p 0.05). B . lactis BL-99 improved the histopathology of the adult zebrafish intestinal inflammation, increased the goblet cell numbers, and up-and-down metabolites were markedly recovered after treatment of B . lactis BL-99 ( p < 0.05). These results suggest that B . lactis BL-99 could relieve intestinal inflammation and promote intestinal functions, at least in part, through modulating intestinal and microbial metabolism to maintain intestinal health.