Open AccessImpact of acute decompensation on the prognosis of patients with hepatocellular carcinoma
Author(s) -
Takayuki Kondo,
Keisuke Koroki,
Hiroaki Kanzaki,
Kazufumi Kobayashi,
Soichiro Kiyono,
Masato Nakamura,
Naoya Kanogawa,
Tomoko Saito,
Satoshi Ogasawara,
Yoshihiko Ooka,
Shingo Nakamoto,
Tetsuhiro Chiba,
Makoto Arai,
Jun Kato,
Satoshi Kuboki,
Masayuki Ohtsuka,
Naoya Kato
Publication year - 2022
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0261619
Subject(s) - medicine , decompensation , hepatocellular carcinoma , cirrhosis , stage (stratigraphy) , gastroenterology , incidence (geometry) , liver function , paleontology , physics , optics , biology
Background/Aims Organ failure in patients with acute decompensation (AD) is a defining characteristic of acute-on-chronic liver failure (ACLF). However, the clinical features of AD during the long-term clinical course of hepatocellular carcinoma (HCC) are still poorly understood. This study aimed to clarify features and impact of AD/ACLF on the prognosis of patients after treatment for HCC. Methods This retrospective study enrolled 556 consecutive patients who were initially diagnosed with HCC, and analyses were conducted taking into account HCC treatment type, HCC stage, and presence or absence of cirrhosis. Results During follow-up, 299 patients with AD were hospitalized. AD occurrence is closely related to prognosis, regardless of the presence or absence of cirrhosis and HCC stage, and early-onset AD (within 90 days after HCC treatment) has negative impact on prognosis. In the intermediate-advanced–stage group, surgical resection had a positive impact on AD incidence post-treatment. After systemic therapy for HCC, renal impairment was the predictive factors for AD development. The 28/90-day mortality rate was higher among 41 cases (13.7%) with AD who exhibited ACLF as compared with cases without ACLF. AD without cirrhosis had similar ACLF incidence and short-term mortality, compared to AD with cirrhosis. The prognostic model using a decision-tree–based approach, which includes ACLF, bilirubin level, HCC progression, and MELD score is useful for predicting 90- or 28-day mortality after AD diagnosis. Conclusions Careful management of patients with HCC who are hospitalized with AD is necessary, considering ACLF, HCC progression, and liver function.