Open AccessIncidence of cervical, breast and colorectal cancers between 2010 and 2015 in people living with HIV in France
Author(s) -
Teresa Rojas Rojas,
Isabelle PoizotMartin,
David Rey,
Claudine Duvivier,
Firouzé BaniSadr,
André Cabié,
Pierre Delobel,
Christine Jacomet,
Clotilde Allavena,
Tristan Ferry,
Pascal Puglièse,
MarcAntoine Valantin,
I. Lamaury,
Laurent Hustache-Matthieu,
A. Frésard,
Tamazighth Houyou,
Thomas Huleux,
Antoine Chéret,
Alain Makinson,
Véronique Obry-Roguet,
C. Lions,
Patrizia Carrieri,
Camélia Protopopescu
Publication year - 2022
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0261069
Subject(s) - medicine , incidence (geometry) , population , confidence interval , coinfection , colorectal cancer , cancer registry , cervical cancer , cohort , breast cancer , cancer , gynecology , human immunodeficiency virus (hiv) , immunology , physics , environmental health , optics
Background We aimed to evaluate the incidence rates between 2010 and 2015 for invasive cervical cancer (ICC), breast cancer (BC), and colorectal cancer (CRC) in people living with HIV (PLWH) in France, and to compare them with those in the French general population. These cancers are targeted by the national cancer-screening program. Setting This is a retrospective study based on the longitudinal data of the French Dat’AIDS cohort. Methods Standardized incidence ratios (SIR) for ICC and BC, and incidence rates for all three cancers were calculated overall and for specific sub-populations according to nadir CD4 cell count, HIV transmission category, HIV diagnosis period, and HCV coinfection. Results The 2010–2015 CRC incidence rate was 25.0 [95% confidence interval (CI): 18.6–33.4] per 100,000 person-years, in 44,642 PLWH (both men and women). Compared with the general population, the ICC incidence rate was significantly higher in HIV-infected women both overall (SIR = 1.93, 95% CI: 1.18–3.14) and in the following sub-populations: nadir CD4 ≤ 200 cells/mm 3 (SIR = 2.62, 95% CI: 1.45–4.74), HIV transmission through intravenous drug use (SIR = 5.14, 95% CI: 1.93–13.70), HCV coinfection (SIR = 3.52, 95% CI: 1.47–8.47) and HIV diagnosis before 2000 (SIR = 2.06, 95% CI: 1.07–3.97). Conversely, the BC incidence rate was significantly lower in the study sample than in the general population (SIR = 0.56, 95% CI: 0.42–0.73). Conclusion The present study showed no significant linear trend between 2010 and 2015 in the incidence rates of the three cancers explored in the PLWH study sample. Specific recommendations for ICC screening are still required for HIV-infected women and should focus on sub-populations at greatest risk.