Open AccessThe association between Helicobacter pylori with nonalcoholic fatty liver disease assessed by controlled attenuation parameter and other metabolic factors
Author(s) -
Yoo Min Han,
Jooyoung Lee,
Ji Min Choi,
MinSun Kwak,
Jong In Yang,
Su Jin Chung,
Jeong Yoon Yim,
Gyung Ho Chung
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0260994
Subject(s) - nonalcoholic fatty liver disease , medicine , gastroenterology , odds ratio , fatty liver , body mass index , helicobacter pylori , confidence interval , metabolic syndrome , triglyceride , obesity , case control study , cholesterol , disease
Aim Existing studies have suggested an association between Helicobacter pylori ( Hp ) infection and nonalcoholic fatty liver disease (NAFLD). We investigated the relationship between Hp infection and NAFLD using controlled attenuation parameter (CAP) and other metabolic factors. Method We conducted a retrospective cohort study of apparently healthy individuals who underwent liver Fibroscan during health screening tests between January 2018 and December 2018. Diagnosis of Hp infection was based on a serum anti- Hp IgG antibody test and CAP values were used to diagnose NAFLD. Results Among the 1,784 subjects (mean age 55.3 years, 83.1% male), 708 (39.7%) subjects showed positive results of Hp serology. In the multivariate analysis, obesity (body mass index ≥25) (odds ratio [OR] 3.44, 95% confidence interval [CI] 2.75–4.29), triglyceride (OR 2.31, 95% CI 1.80–2.97), and the highest tertile of liver stiffness measurement (OR 2.08, 95% CI 1.59–2.71) were found to be associated with NAFLD, defined by CAP ≥248 dB/m, while Hp -seropositivity showed no association with NAFLD. Serum levels of HDL cholesterol significantly decreased in subjects with Hp -seropositivity compared to HP- seronegativity in both groups with and without NAFLD ( P <0.001). Conclusion While Hp seropositivity was not associated with CAP-defined NAFLD, serum HDL cholesterol level were negatively associated with Hp -seropositivity in both groups with and without NAFLD. Further clinical and experimental studies are necessary to determine the association between Hp infection and NAFLD.