Open AccessA machine learning framework for the evaluation of myocardial rotation in patients with noncompaction cardiomyopathy
Author(s) -
Marcelo Dantas Tavares de Melo,
José de Arimateia Batista Araújo-Filho,
José Raimundo Barbosa,
Camila Rocon,
Carlos Danilo Miranda Regis,
Alex dos Santos Félix,
Roberto Kalil Filho,
Edimar Alcides Bocchi,
Ludhmila Abrahão Hajjar,
Mahdi Tabassian,
Jan D’hooge,
Vera Maria Cury Salemi
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0260195
Subject(s) - ejection fraction , medicine , ventricle , cardiology , cardiomyopathy , diastole , magnetic resonance imaging , left ventricular noncompaction , cardiac magnetic resonance imaging , random forest , algorithm , heart failure , radiology , machine learning , blood pressure , mathematics , computer science
Aims Noncompaction cardiomyopathy (NCC) is considered a genetic cardiomyopathy with unknown pathophysiological mechanisms. We propose to evaluate echocardiographic predictors for rigid body rotation (RBR) in NCC using a machine learning (ML) based model. Methods and results Forty-nine outpatients with NCC diagnosis by echocardiography and magnetic resonance imaging (21 men, 42.8±14.8 years) were included. A comprehensive echocardiogram was performed. The layer-specific strain was analyzed from the apical two-, three, four-chamber views, short axis, and focused right ventricle views using 2D echocardiography (2DE) software. RBR was present in 44.9% of patients, and this group presented increased LV mass indexed (118±43.4 vs. 94.1±27.1g/m 2 , P = 0.034), LV end-diastolic and end-systolic volumes ( P < 0.001), E/e’ (12.2±8.68 vs. 7.69±3.13, P = 0.034), and decreased LV ejection fraction (40.7±8.71 vs. 58.9±8.76%, P < 0.001) when compared to patients without RBR. Also, patients with RBR presented a significant decrease of global longitudinal, radial, and circumferential strain. When ML model based on a random forest algorithm and a neural network model was applied, it found that twist, NC/C, torsion, LV ejection fraction, and diastolic dysfunction are the strongest predictors to RBR with accuracy, sensitivity, specificity, area under the curve of 0.93, 0.99, 0.80, and 0.88, respectively. Conclusion In this study, a random forest algorithm was capable of selecting the best echocardiographic predictors to RBR pattern in NCC patients, which was consistent with worse systolic, diastolic, and myocardium deformation indices. Prospective studies are warranted to evaluate the role of this tool for NCC risk stratification.