Open AccessClinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study
Author(s) -
Ezequiel Córdova,
Analía Mykietiuk,
Omar Sued,
Lautaro De Vedia,
Natalia Pacífico,
Matias H. Garcia Hernandez,
Natalia Baeza,
F. Garibaldi,
María Fernanda Alzogaray,
Rosa Contreras,
Lucrecia Soler Puy,
Pablo Scapellato,
Laura Barcelona,
Mariana L. Golikow,
María Florencia Piñeiro,
Hugo J. Miño,
María Fernanda Consalvo,
Coriemirovsky,
Marisa Sánchez,
Myrna Cabral,
Lucía Lamponi Tappatá,
Mariano Blasco,
Jamile Ballivian,
Gustavo Lopardo,
Martín E. Stryjewski
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0258260
Subject(s) - medicine , latin americans , covid-19 , prospective cohort study , multicenter study , betacoronavirus , medline , intensive care medicine , pediatrics , virology , biology , outbreak , disease , infectious disease (medical specialty) , randomized controlled trial , philosophy , linguistics , biochemistry
Background Clinical features and outcomes of SARS-CoV-2 infections diverge in different countries. The aim of this study was to describe clinical characteristics and outcomes in a cohort of patients hospitalized with SARS-CoV-2 in Argentina. Methods Multicenter prospective cohort study of ≥18 years-old patients with confirmed SARS-CoV-2 infection consecutively admitted to 19 hospitals in Argentina. Multivariable logistic regression models were used to identify variables associated with 30-day mortality and admission to intensive care unit (ICU). Results A total of 809 patients were analyzed. Median age was 53 years, 56% were males and 71% had at least one comorbidity. The most common comorbidities were hypertension (32%), obesity (23%) and diabetes (17%). Disease severity at admission was classified as mild 25%, moderate 51%, severe 17%, and critical 7%. Almost half of patients (49%) required supplemental oxygen, 18% ICU, and 12% invasive ventilation. Overall, 30-day mortality was 11%. Factors independently associated with ICU admission were male gender (OR 1.81; 95%CI 1.16–2.81), hypertension (OR 3.21; 95%CI 2.08–4.95), obesity (OR 2.38; 95%CI 1.51–3.7), oxygen saturation ≤93% (OR 6.45; 95%CI 4.20–9.92) and lymphopenia (OR 3.21; 95%CI 2.08–4.95). Factors independently associated with 30-day mortality included age ≥60 years-old (OR 2.68; 95% CI 1.63–4.43), oxygen saturation ≤93% (OR 3.19; 95%CI 1.97–5.16) and lymphopenia (OR 2.65; 95%CI 1.64–4.27). Conclusions This cohort validates crucial clinical data on patients hospitalized with SARS-CoV-2 in Argentina.