Open AccessAre neighbourhoods of tuberculosis cases a high-risk population for active intervention? A protocol for tuberculosis active case finding
Author(s) -
Bachti Alisjahbana,
Raspati Cundarani Koesoemadinata,
Panji Fortuna Hadisoemarto,
Bony Wiem Lestari,
Sri Hartati,
Lidya Chaidir,
Chuan-Chin Huang,
Megan Murray,
Philip C. Hill,
Susan McAllister
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0256043
Subject(s) - tuberculosis , medicine , environmental health , transmission (telecommunications) , sputum , epidemiology , mycobacterium tuberculosis , population , case finding , public health , extensively drug resistant tuberculosis , incidence (geometry) , demography , pathology , physics , electrical engineering , optics , engineering , sociology
Background Indonesia has the second largest tuberculosis (TB) burden globally. Attempts to scale-up TB control efforts have focused on TB households. However, in most high burden settings, considerable Mycobacterium tuberculosis (Mtb) transmission occurs outside TB households. A better understanding of transmission dynamics in an urban setting in Indonesia will be crucial for the TB Control Program in scaling up efforts towards elimination of TB in a more targeted way. Therefore, the study aims to measure TB prevalence and incidence in household contacts and neighbourhoods in the vicinity of known TB cases and to assess their genomic and epidemiological relatedness. Methods and analysis Individuals (~1000) living in the same household as a case diagnosed with pulmonary TB (n = 250) or in a neighbouring household (~4500 individuals) will be screened for TB symptoms and by chest x-ray. Two sputum samples will be collected for microbiological analysis from anyone with a productive cough. Any person found to have TB will be treated by the National TB Control Program. All those with no evidence of TB disease will have a repeat screen at 12 months. Whole-genome sequencing (WGS) and social network analysis (SNA) will be conducted on Index cases and contacts diagnosed with TB.