Open AccessEffects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system
Author(s) -
I. G. Shalaginova,
Oksana Tuchina,
Maria Sidorova,
A. S. Levina,
Diana A.-A. Khlebaeva,
А. И. Вайдо,
N. A. Dyuzhikova
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0255380
Subject(s) - inflammation , central nervous system , hippocampus , medicine , peripheral , autonomic nervous system , nervous system , sympathetic nervous system , immunology , neuroscience , biology , blood pressure , heart rate
Patients with post-stress pathologies display the signs of inflammation in the peripheral blood as well as in the brain. The mechanisms of such post-stress neuroimmune changes, their contribution to the behavior, the relationship of the intensity of inflammation with genetically determined features have not been clarified. The goal of this work was to evaluate the dynamics of post-stress inflammation in the blood and hippocampus of rats which differ in level of excitability of the nervous system. Rats of two strains (high/low excitability threshold) were subjected to stress according to the K. Hecht protocol and their behavior, neutrophil:lymphocyte ratio and the number of Iba+ cells in the hippocampus were analysed 24 hours, 7 and 24 days after stress exposure. Highly excitable animals show an increase in anxiety-like behavior, in the number of neutrophils compared to lymphocytes as well as in the number of Iba1+ cells in CA1, CA3 and DG areas of the hippocampus in response to stress. Thus, hereditary high excitability of the nervous system is a possible risk factor for the development of post-stress pathologies.