Open AccessPoly(amino acid) based fibrous membranes with tuneable in vivo biodegradation
Author(s) -
Kristóf Molnár,
Constantinos Voniatis,
D. Fehér,
G. Szabó,
Rita Varga,
Lilla Reiniger,
Dávid Juriga,
Zoltán Kiss,
Enikő Krisch,
György Wéber,
Andrea Ferencz,
Gábor Varga,
Miklós Zrı́nyi,
Krisztigy,
Angéla JedlovszkyHajdú
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0254843
Subject(s) - membrane , in vivo , biocompatibility , biodegradation , ultimate tensile strength , hydrolysis , materials science , chemistry , alkyl , polymer chemistry , biomedical engineering , biophysics , biochemistry , organic chemistry , composite material , biology , medicine , microbiology and biotechnology
In this work two types of biodegradable polysuccinimide-based, electrospun fibrous membranes are presented. One contains disulfide bonds exhibiting a shorter (3 days) in vivo biodegradation time, while the other one has alkyl crosslinks and a longer biodegradation time (more than 7 days). According to the mechanical measurements, the tensile strength of the membranes is comparable to those of soft the connective tissues and visceral tissues. Furthermore, the suture retention test suggests, that the membranes would withstand surgical handling and in vivo fixation. The in vivo biocompatibility study demonstrates how membranes undergo in vivo hydrolysis and by the 3 rd day they become poly(aspartic acid) fibrous membranes, which can be then enzymatically degraded. After one week, the disulfide crosslinked membranes almost completely degrade, while the alkyl-chain crosslinked ones mildly lose their integrity as the surrounding tissue invades them. Histopathology revealed mild acute inflammation, which diminished to a minimal level after seven days.