Open AccessTrends of HIV/Syphilis/HSV-2 seropositive rate and factors associated with HSV-2 infection in men who have sex with men in Shenzhen, China: A retrospective study
Author(s) -
Shasha Mao,
Shuidong Feng,
Chenli Zheng,
Wei Hu,
Hao Li,
Jie Tang,
Zheng Yang,
Jin Zhao
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0251929
Subject(s) - syphilis , medicine , demography , logistic regression , men who have sex with men , condom , marital status , coinfection , immunology , human immunodeficiency virus (hiv) , environmental health , population , sociology
Objectives To analyze the trends of HIV/syphilis/HSV-2 seropositive rate and explore the related factors with HSV-2 infection to provide the basis for adjusting STD intervention strategies and formulating prevention and control measures among MSM in Shenzhen. Methods Time-location sampling was conducted among MSM in Shenzhen in 2012, 2014, 2016, and 2018. Data on demographics, sexual behaviors and the laboratory test results of HIV, syphilis, HSV-2 were collected. The χ 2 trend test was used to analyze the trends of HIV/syphilis/HSV-2 seropositive rate. The binary logistic regression model was used to explore the factors associated with HSV-2 infection. Results The seropositive rate of HIV fell significantly from 15.9% in 2012 to 8.7% in 2018 ( P trend = 0.003), syphilis seropositive rate was significantly decreased from 20.4% in 2012 to 14.8% in 2018 ( P trend = 0.025), HSV-2 seropositive rate had no significant change (16.7% in 2012 to 14.0% in 2018; P trend = 0.617). In principal component logistic regression analysis showed that FAC1_1 (X 1 = Ever had sex with female, X 2 = Gender of first sexual partner, X 3 = Marital status, X 4 = Age group), FAC2_1 (X 5 = Education, X 6 = Monthly income (RMB), X 7 = Frequency of condom use in anal sex with men in the past 6 months), and FAC4_1 (X 9 = History of STDs) were significantly associated with HSV-2 infection. Conclusions The seropositive rates of HIV and syphilis have dropped significantly but are still high. HSV-2 seropositive rate had no significant change and maintained a high level. It is necessary to continue strengthening HIV and syphilis interventions among MSM in Shenzhen. HSV-2 detection and intervention are urgently required for MSM, which might be another effective biological strategy further to control the HIV epidemic among MSM in Shenzhen.