Open AccessDoes varying the ingestion period of sodium citrate influence blood alkalosis and gastrointestinal symptoms?
Author(s) -
Charles S. Urwin,
Rodney J. Snow,
Liliana Orellana,
Dominique Condo,
Glenn D. Wadley,
Amelia J. Carr
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0251808
Subject(s) - ingestion , alkalosis , metabolic alkalosis , sodium citrate , sodium , medicine , venous blood , chemistry , zoology , acidosis , biology , pathology , organic chemistry
Objectives To compare blood alkalosis, gastrointestinal symptoms and indicators of strong ion difference after ingestion of 500 mg.kg -1 BM sodium citrate over four different periods. Methods Sixteen healthy and active participants ingested 500 mg.kg -1 BM sodium citrate in gelatine capsules over a 15, 30, 45 or 60 min period using a randomized cross-over experimental design. Gastrointestinal symptoms questionnaires and venous blood samples were collected before ingestion, immediately post-ingestion, and every 30 min for 480 min post-ingestion. Blood samples were analysed for blood pH, [HCO 3 - ], [Na + ], [Cl - ] and plasma [citrate]. Linear mixed models were used to estimate the effect of the ingestion protocols. Results For all treatments, blood [HCO 3 - ] was significantly elevated above baseline for the entire 480 min post-ingestion period, and peak occurred 180 min post-ingestion. Blood [HCO 3 - ] and pH were significantly elevated above baseline and not significantly below the peak between 150–270 min post-ingestion. Furthermore, blood pH and [HCO 3 - ] were significantly lower for the 60 min ingestion period when compared to the other treatments. Gastrointestinal symptoms were minor for all treatments; the mean total session symptoms ratings (all times summed together) were between 9.8 and 11.6 from a maximum possible rating of 720. Conclusion Based on the findings of this investigation, sodium citrate should be ingested over a period of less than 60 min (15, 30 or 45 min), and completed 150–270 min before exercise.